M anchineel is native to Florida in the United States, and the Caribbean coast. It holds the Guinness record for the world's most dangerous tree. It is extremely toxic; every part of it is poisonous. Its leaves, branches and bark secrete a highly toxic white creamy sap that causes burning, skin irritation. You don't actually have to touch it to be harmed. Even a single drop of rain, which has touched the Manchineel, can cause severe burns and blisters on the skin and even blindness can occur if it touches a person´s eye.